Thioridazine reverts the phenotype in cellular and Drosophila models of amyotrophic lateral sclerosis by enhancing TDP-43 aggregate clearance

Brain inclusions mainly composed of misfolded and aggregated TAR DNA binding protein 43 (TDP-43), are characteristic hallmarks of amyotrophic lateral sclerosis (ALS).Irrespective of the role played by the inclusions, their reduction represents an important therapeutic pathway that is worth exploring.Their removal can either lead to the recovery of

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Dermatologic symptoms associated with gastrointestinal neoplasia

Gastrointestinal tumors are among the most common neoplastic causes of death worldwide.Presence of characteristic Waste Tank skin lesions can allow faster diagnosis and therapy and this way can increase the probability of a cure.In the paper we present the most important paraneoplastic syndromes that can coexist with gastrointestinal malignancy inc

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Flow Field Simulation for High Speed Train Gearbox

Regarding the gearbox of a certain type high speed train as the research object, the simulation and analysis of the complex internal flow field during its normal operation was carried out.Three-dimensional model of the gearbox oil lubrication was built, and its internal flow field was calculated by using professional fluid simulation software Pumpl

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